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FLASH GENE
Symbol PRPF4 contributors: npt/mct - updated : 01-12-2015
HGNC name PRP4 pre-mRNA processing factor 4 homolog (yeast)
HGNC id 17349
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrinethyroid   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven WD motifs in the C terminal region
  • five or more CAG repeats
  • mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae prp4
    Homologene
    FAMILY
    CATEGORY RNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,kinetochore
    basic FUNCTION
  • U4/U6 small nuclear ribonucleoprotein associated splicing factor
  • kinetochore component that is necessary to establish a functional spindle assembly checkpoint
  • PRPF4-mediated phosphorylation of KLF13 plays a role in the regulation of CCL5 expression in T lymphocytes
  • roles in regulating pre-mRNA splicing
  • requirement of enzymatic activity of PRPF4 in regulating cancer cell growth
  • CELLULAR PROCESS nucleotide, transcription, maturation
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the spliceosome
  • INTERACTION
    DNA
    RNA binding to U4 and U6 snRNAs
    small molecule
    protein
  • HPRP3P
  • checkpoint protein required for MAD1L1, and MAD2L1 localization to the kinetochores
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RP70
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS