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FLASH GENE
Symbol SUGT1 contributors: mct - updated : 19-12-2012
HGNC name SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
HGNC id 16987
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Endocrinepancreas   highly
Respiratorylung    
Skin/Tegumentskin   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
Respiratoryalveolar macrophage
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, checkpoint, G1S, G2M
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region containing a tetratricopeptide repeat (TPR)
  • one central CS domain
  • a C-terminal SGS domain (SGT1-specific)
  • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae Sgt1p
    homolog to murine Sugt1 (87.7pc)
    homolog to rattus Sugt1 (87.7pc)
    Homologene
    FAMILY
    CATEGORY adaptor , chaperone/stress , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • dynamically localizes at the kinetochores, which lack microtubule attachments during prometaphase
  • increase in intracellular concentration of Ca(2+), transduced by S100A6, is necessary for nuclear translocation of the SUGT1 protein
  • basic FUNCTION
  • centromere/kinetochore complex maturation
  • involved in kinetochore function and required for the G1/S and G2/M transitions
  • essential protein and critical assembly factor for the kinetochore
  • activator of CTF13 protein
  • may play a role in ubiquitination and subsequent proteosomal degradation of target proteins
  • adaptor protein playing an essential role in signaling pathways linked to activation of NOD1 in epithelial lineage cells
  • co-chaperone protein with an expression pattern matching that of the well known heat shock proteins
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, progression
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • associating with the SCF complex (SKP1/CDC53/F box protein) and ubiquitin ligase complex
  • multiprotein complex with NOD1 that includes HSP90
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SKP1A/B
  • positively regulates NOD1 activation
  • ITG1BP2 interacts with SUGT1, an HSP90AA1 binding molecule
  • increase in intracellular concentration of Ca(2+), transduced by S100A6, is necessary for nuclear translocation of the SUGT1 protein
  • S100A6-SUGT1 dephosphorylation promotes its nuclear translocation, most likely due to disruption of the SUGT1-HSP90AA1 complex
  • cochaperone for HSP90AA1, 1s a novel PLK1 substrate during mitosis
  • cell & other
    REGULATION
    Phosphorylated by PLK1, that is required for the kinetochore localization of SUGT1 and phosphorylates serine 331 of SUGT1 at the kinetochores
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    might give rise to promote the transcription of the gene directly subsequent to the progression of colorectal cancer cases with worsening prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS