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FLASH GENE
Symbol B3GNT5 contributors: npt - updated : 19-02-2002
HGNC name UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
HGNC id 15684
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • beta 3 Gn-T motifs
  • HOMOLOGY
    interspecies ortholog to murine B3gnt5
    Homologene
    FAMILY
  • glycosyltransferase 31 family
  • beta-1,3-N-acetylglucosaminyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane protein
    basic FUNCTION
  • exhibits strong activity to transfer GlcNAc to glycolipid substrates and is the most likely candidate for lactotriaosylceramide synthase
  • may be playing a role in regulating neolacto-series glycolipid synthesis during embryonic development
  • is essential for the expression of Lewis X epitopes on glycolipids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text brain morphogenesis
    PATHWAY
    metabolism carbohydrate
    signaling
    expression of HNK-1 and Lewis x epitopes on glycolipids
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by 12-O-tetradecamoylphorbol-13-acetate
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS