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FLASH GENE
Symbol ELMO3 contributors: mct/npt - updated : 25-08-2014
HGNC name engulfment and cell motility 3
HGNC id 17289
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrinethyroid   highly
Reproductivemale systemprostate   
Respiratoryrespiratory tractlarynx  highly
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • an ELMO domain
  • a PH domain
  • HOMOLOGY
    interspecies ortholog to C.elegans
    ortholog to Drosophila Ced12
    intraspecies paralog to ELMO1,ELMO2
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • upstream regulator of AKT1 required for engulfment of dying cells and for cell migration
  • involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility
  • unexpected role for ELMO1, ELMO2, ELMO3 in recruiting MACF1 at the membrane to promote efficient microtubule capture in cells spreading on fibronectin
  • CELLULAR PROCESS cell life, cell death/apoptosis
    cell communication
    PHYSIOLOGICAL PROCESS
    text cytoskeletal rearrangements during phagocytosis and cell motility in the late steps of the apoptotic process (complementation group 2 in C elegans)
    PATHWAY
    metabolism
    signaling
    signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts directly with the SH3-domain of DOCK1 via its SH3-binding site
  • is an essential upstream regulator of the GTP-binding protein AKT1 during cell migration
  • CDX2 and SP1 can activate the ELMO3 promoter
  • MACF1 interacts with ELMO2 and ELMO3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS