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FLASH GENE
Symbol RAPGEF5 contributors: np - updated : 26-03-2003
HGNC name Rap guanine nucleotide exchange factor (GEF) 5
HGNC id 16862
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Ras-GEF domain
  • PDZ domain containing guanine nucleotide exchange factor (GEF)1
  • HOMOLOGY
    Homologene
    FAMILY
  • guanine nucleotide exchange factor for Ras-like GTPases family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION activating Rap1
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding specifically to nucleotide-free Rap1
  • binding M-Ras-GTP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS