Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UGGT2 contributors: mct - updated : 19-11-2014
HGNC name UDP-glucose ceramide glucosyltransferase-like 2
HGNC id 15664
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
 vessel   moderately
Digestiveliver    
Endocrinepancreas    
 parathyroid   predominantly
Hearing/Equilibriumear   highly
Nervousbrain    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  moderately
Connectivebone  highly
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 27 aa signal pepide of 2.8 kda
  • a predicted ER-targeting signal sequence
  • a putative ER retrieval signal
  • four putative N-glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Ugcgl2 (78.6 pc)
    intraspecies homolog to UGGT1
    Homologene
    FAMILY
  • glycosyltransferase 8 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text ER-Golgi intermediate compartment
    basic FUNCTION
  • recognizing glycoproteins with minor folding defects
  • reglucosylating single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum
  • having a glucosyltransferase activity, whose specificity was shown to be quite similar to UGGT1, in terms of both glycan specificity and preferential recognition of proteins having non-native conformations
  • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS
    text
  • protein glycosylation
  • PATHWAY
    metabolism
    signaling
    a component UGGT1 and UGGT2 are central component of the endoplasmic reticulum (ER) glycoprotein-folding quality control system, which prevents the exit of partially folded species
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Ca2+
  • Mn2+
  • protein
  • hormonal regulation of UGGT1 and UGGT2 expression and activity, which might influence the glycoprotein quality control mechanism
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS