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FLASH GENE
Symbol GNA13 contributors: mct - updated : 06-04-2013
HGNC name guanine nucleotide binding protein (G protein), alpha 13
HGNC id 4381
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Lymphoid/Immunelymph node   highly
 thymus   highly
cell lineage
cell lines HPB-ALL leukemic T cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP
mono polymer heteromer , trimer
HOMOLOGY
interspecies homolog to C.elegans F18G5.3
Homologene
FAMILY
  • G alpha family
  • G(12) subfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • participating in the regulation of cell movement in response to specific ligands and in developmental angiogenesis
  • involved as modulators or transducers in various transmembrane signaling systems
  • regulating cell growth and differentiation through the monomeric Rho GTPase
  • required for the embryonic angiogenesis (Liu 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • three units : alpha, beta and gamma
  • the alpha chain contains the guanine nucleotide binding site
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARHGEF1
  • DRD3 interaction with GNA12/GNA13 that increases sodium excretion may have a role in the regulation of blood pressure
  • ITK interacts with GNA13 during TCR triggering, and this interaction results in tyrosine phosphorylation of GNA13
  • GPR56 regulates oligodendrocyte development via interactions with GNA12/GNA13 and RHOA
  • RGS22 had specific interactions with the heterotrimeric G protein GNA12 and GNA13 in the cells
  • cell & other
    REGULATION
    Other regulated by myocyte-specific enhancer factor-2 (MEF2) mediating GNA13-dependent angiogenesis (Liu 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    of endogenous GNA13 and MEF2 proteins in endothelial cells reduced cell proliferation and capillary tube formation (Liu 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS