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FLASH GENE
Symbol GNG11 contributors: npt/mct - updated : 15/102008
HGNC name guanine nucleotide binding protein (G protein), gamma 11
HGNC id 4403
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure alpha, beta, gamma subunit
mono polymer heteromer , trimer
HOMOLOGY
interspecies homolog to C.elegans K02A4.2
Homologene
FAMILY
  • G protein gamma family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • plays a role in the transmembrane signaling system
  • mediating a senescence pathway in response to environmental cues
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterotrimeric G protein complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by senescence-inducing agents such as H(2)O(2)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in splenic marginal zone lymphomas
    constitutional     --over  
    immediately induces cellular senescence in normal fibroblasts, and its down-regulation by antisense cDNA extends their lifespan
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS