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FLASH GENE
Symbol PDLIM1 contributors: mct/pgu - updated : 03-07-2018
HGNC name PDZ and LIM domain 1 (elfin)
HGNC id 2067
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
 pharynx   highly
Endocrinepancreas   lowly
Lymphoid/Immunespleen   highly
 tonsils   highly
Nervousgangliasensory gangliadorsal root highly Homo sapiens
Reproductivefemale systemplacenta  highly
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta, exclusively expressed in the cytotrophoblast layer
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal PDZ motif, essential for CLP36 to function
  • LIM domain at the C terminus, essential for CLP36 to function
  • HOMOLOGY
    interspecies ortholog to rattus Clp36
    Homologene
    FAMILY
  • ALP subfamily of PDZ-LIM proteins
  • enigma family of proteins
  • CATEGORY adaptor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    text
  • PDLIM1 and palladin were colocalized in the neurites and cell bodies of primary DRG neurons
  • forms a complex with alpha-actinin and is localized to actin cytoskeleton
  • in platelets, the PDZ domain of PDLIM1 has been shown to build a bridge between stress fibers and ACTN1 and to link plasma membrane Ca2+ ATPase 4b to the actin cytoskeleton
  • basic FUNCTION
  • cytoskeletal protein acting as an adaptor that brings other proteins to the cytoskeleton
  • involved in the cytoskeletal reorganization and signal transduction of a variety of cells
  • playing an essential role for the assembly of stress fibers and focal adhesions
  • regulate the biological activity of ESR1 during the development of breast cancer
  • serves as a scaffold to form a multiprotein complex that regulates actin cytoskeleton dynamics and plays a role in controlling neurite outgrowth
  • plays a role in neurite outgrowth in the peripheral nervous system
  • may interact with palladin to influence neurite outgrowth during sciatic nerve regeneration
  • is dispensable for actin rearrangements in platelets
  • is an important regulator of platelet activation
  • is an important regulator of breast cancer cell migration and metastasis
  • PDLIM1 suppresses EMT and metastatic potential of colorectal cancer cells by stabilizing CTNNB1 at cell-cell junctions
  • degradation of PDLIM1 by autophagy in Sertoli cells is important for the proper assembly of the ectoplasmic specialization (ES), and these findings define a novel role for autophagy in Sertoli cell-germ cell communication
  • autophagy regulates cytoskeleton organization mainly via degradation of PDLIM1 to facilitate the differentiation of spermatids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • PDLIM1 and palladin formed a complex in the dorsal root ganglion (DRG)
  • FHL1 exists as part of a complex that binds with PDLIM1, GSN and ACTN1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • alpha-activing 1, 2, 4-(ACTN1, ACTN2, ACTN4)
  • PALLD is a PDLIM1-binding protein
  • acts as a negative regulator of GP6 signaling, and acts as a negative regulator of GP6 signaling also under flow
  • PDLIM1 negatively regulates NFKB1-mediated signaling in the cytoplasm (PDLIM1 sequestered p65 subunit of NFKB1 in the cytoplasm and suppressed its nuclear translocation in an NFKBIA-independent, but ACTN4-dependent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    up-regulated in dorsal root ganglion neurons and facial motoneurons after nerve injury
    constitutional       loss of function
    results in markedly enhanced platelet activation in response to collagen and a prothrombotic phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • PDLIM1 loss in metastatic tissues may represent a potential prognostic marker of aggressive disease
  • Therapy target
    SystemTypeDisorderPubmed
    bloodcoagulation 
    might provide a basis for the development of novel strategies to control intravascular platelet activation
    ANIMAL & CELL MODELS