basic FUNCTION
| cytoskeletal protein acting as an adaptor that brings other proteins to the cytoskeleton |
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involved in the cytoskeletal reorganization and signal transduction of a variety of cells |
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playing an essential role for the assembly of stress fibers and focal adhesions |
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regulate the biological activity of ESR1 during the development of breast cancer |
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serves as a scaffold to form a multiprotein complex that regulates actin cytoskeleton dynamics and plays a role in controlling neurite outgrowth |
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plays a role in neurite outgrowth in the peripheral nervous system |
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may interact with palladin to influence neurite outgrowth during sciatic nerve regeneration |
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is dispensable for actin rearrangements in platelets |
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is an important regulator of platelet activation |
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is an important regulator of breast cancer cell migration and metastasis |
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PDLIM1 suppresses EMT and metastatic potential of colorectal cancer cells by stabilizing CTNNB1 at cell-cell junctions |
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degradation of PDLIM1 by autophagy in Sertoli cells is important for the proper assembly of the ectoplasmic specialization (ES), and these findings define a novel role for autophagy in Sertoli cell-germ cell communication |
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autophagy regulates cytoskeleton organization mainly via degradation of PDLIM1 to facilitate the differentiation of spermatids |