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FLASH GENE
Symbol PKP4 contributors: mct - updated : 27-09-2017
HGNC name plakophilin 4
HGNC id 9026
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Hearing/Equilibriumear   predominantly
Nervousbrain   moderately
 nerve   moderately
Reproductivefemale systembreastmammary gland moderately
 female systemuteruscervix moderately
Respiratoryrespiratory tractlarynx  highly
Urinarybladder   moderately
 kidney   moderately
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine ARM repeats
  • a conserved central domain consisting of a series of repeated motifs, the armadillo repeats, which is flanked by more diverse N- and C-terminal domains
  • HOMOLOGY
    interspecies homolog to rattus Pkp4 (96.6 pc)
    homolog to murine Pkp4 (96.6 pc)
    Homologene
    FAMILY
  • Armadillo proteins family
  • p120 catenin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
    plasma membrane,junction,desmosome
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • myofibrils
  • colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells
  • localized as a plaque protein in adhaerens junctions (AJs) of diverse epithelia and certain vascular endothelia, in the composite junctions (areal compositae) of the intercalated disks of cardiomyocytes
  • junctional plaque component involved in cell-cell adhesion, especially in adherens junctions
  • basic FUNCTION
  • regulating functional plaque organization and cadherin function
  • playing an essential role in spatially regulating restricted Rho signalling during cytokinesis
  • armadillo protein that is localized at the midbody during cytokinesis and is essential for cell division
  • plays a role in cytokinesis, in which it regulates local activation of RHOA together with ECT2
  • PKP4 and ECT2 are transported via distinct motors, identifying a novel pathway implicating KIF3B in the regulation of actin organization during cytokinesis
  • is an intercellular junction protein of the p120 catenin family
  • has likely a key role in regulating recycling through the RAB11A-dependent perinuclear recycling compartment, and links the regulation of adherens junctions to recycling to allow dynamic modulation of intercellular adhesion
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PDZD2
  • full activation of RHOA required ECT2 as well as PKP4 indicating that these two proteins act in conjunction to regulate RHOA during cytokinesis
  • PKP4 is a potential novel FLCN interacting protein
  • is an important and novel FMR1 target, strongly suggesting that impaired actin cytoskeletal functions mediated by an excess of PKP4 are key aspects underlying the fragile X syndrome
  • RAB11A is a novel interaction partner of PKP4
  • directly interacts with the KIF3/subunit KIF3B, and also interacts with the kinesin cargo adaptor protein KIFAP3 acting as a stabilizing linker between KIF3B and its KIFAP3 cargo binding entity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS