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FLASH GENE
Symbol SF3B2 contributors: mct/npt - updated : 17/09/2008
HGNC name splicing factor 3b, subunit 2, 145kDa
HGNC id 10769
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Nervousspinal cord   highly
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a proline-rich N terminus
  • a CUS1 domain
  • a glutamate rich stretch in the C-terminus
  • lacking RNA binding motifs
  • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae cus1
    ortholog to C.elegans zk.632.1
    Homologene
    FAMILY
  • SnRNP associated proteins family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for the assembly of spliceosomal complex
  • playing with SF3B4 roles in cell cycle progression
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the "a" complex in the spliceosome assembly pathway
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • U2SnRNP, U11/U12SnRNP associated splice protein
  • associating with other SF3b proteins, interacting directly with SAP49(SF3B4)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS