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FLASH GENE
Symbol SLC13A3 contributors: mct - updated : 28-02-2014
HGNC name solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
HGNC id 14430
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   moderately
Hearing/Equilibriumear   highly
Reproductivefemale systemplacenta  highly
Urinarykidneytubuleconvoluted tubuleproximal tubulehighly
 kidneynephron   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • di-hydrophobic amino acid motif VW as basolateral localization signal in the N-terminal cytoplasmic domain
  • three putative N linked glycosylation sites
  • twelve transmembrane domains
  • eight potential protein kinase C dependent phosphorylation sites
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text synaptosomes
    basic FUNCTION
  • high-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms
  • SLC13A2 , SLC13A5 and SLC13A3, transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate
  • participates in drug and xenobiotic excretion through interactions with organic anion transporters
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text sodium sulfate symporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS