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FLASH GENE
Symbol IMP3 contributors: mct - updated : 30-08-2016
HGNC name IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
HGNC id 14497
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Lymphoid/Immunetonsils    
Reproductivefemale systemuteruscervix  
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervous    
cell lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a S4 RNA-binding domain
  • conjugated RiboP
    mono polymer heteromer , trimer , complex
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Imp3p
    homolog to murine Imp3 (96.2pc)
    Homologene
    FAMILY
  • ribosomal protein S4P family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • required for the early cleavages during pre-18S ribosomal RNA processing
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP)
  • component of a heterotrimeric complex containing IMP3, IMP4 and KIF20B
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with the U3 snoRNP complex
  • interacting with KIF20B
  • IMP3 facilitates the transcription of SNAI2, which is necessary for TAZ nuclear localization and activation, by a mechanism that is also mediated by WNT5B
  • cell & other
    REGULATION
    Other the formation of the ternary complex of IMP3, IMP4 and MPP10 is required for their association with nucleolar components
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS