Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ABCC11 contributors: mct - updated : 08-12-2021
HGNC name ATP-binding cassette, sub-family C (CFTR/MRP), member 11
HGNC id 14639
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 stomachmucous gland  highly Homo sapiens
Nervousbrain   lowly
Reproductivefemale systembreastmammary gland  
 male systemprostate  lowly
 male systemtestis  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium (mucosa) highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text lowly in placenta and fetal brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two ATP-binding domains
  • two transmembrane regions
  • HOMOLOGY
    intraspecies homolog to MRP5
    Homologene
    FAMILY ATP binding cassette transporter subfamily C (CFTR/MRP)
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microfilament
    text co-localized with neurofilaments indicating that it is an axonal protein
    basic FUNCTION
  • acting as a multispecific organic anion pump which can transport nucleotides
  • involved in multi-drug resistance
  • playing a role in dehydroepiandrosterone 3-sulfate release from neurons to sites of dehydroepiandrosterone 3-sulfate-mediated receptor modulation
  • likely playing an important role in the generation of axillary malodour
  • plasma membrane protein involved in the transport of a variety of lipophilic anions
  • novel function of ABCC11/MRP8 in the regulation of pepsinogen I secretion in the normal gastric chief cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP-binding
    protein
    cell & other
    REGULATION
    Other N-linked glycosylation is likely important for the protein stability of ABCC11
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    expressed in aggressive breast cancer subtypes, and is associated with poor prognosis
    Susceptibility
  • to earwax type
  • to axillary osmidrosis
  • Variant & Polymorphism SNP
  • determinant of earwax type
  • SNP ABCC11 538G>A (G180R) is linked to axillary osmidrosis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS