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FLASH GENE
Symbol ABCA13 contributors: mct/npt - updated : 28-05-2015
HGNC name ATP-binding cassette, sub-family A (ABC1), member 13
HGNC id 14638
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 mouth    
Nervousbrainlimbic systemhippocampus highly
 brainforebraincerebral cortex highly
Reproductivemale systemtestis   
Respiratoryrespiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal hydrophobic transmembrane domain
  • a large hydrophilic region
  • two cytoplasmic nucleotide binding domains (NBDs), the latter containing characteristic ATP-binding Walker A and B motifs
  • two transmembrane domains (TMDs)
  • a conserved hydrophobic membrane-dipping region (HDR)
  • conserved C-terminal motif known to be shared among the lipid transporting group suggesting that it is likely to be lipid related (Knight 2009)
  • conjugated Other
    HOMOLOGY
    Homologene
    FAMILY
  • ATP binding cassette transporter family
  • ABCA subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • shuttles lipid molecules across cell membranes (Knight 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia and bipolar disorder
    Variant & Polymorphism other 10 rare nonsynonymous mutations of which 9 demonstrated evidence consistent with a role in the etiology of schizophrenia and bipolar disorder (Knight 2009)
    Candidate gene
    Marker
  • CIAPIN1 and ABCA13 may be novel markers of poor outcome in pre-chemotherapy ovarian serous carcinoma effusions
  • Therapy target
    ANIMAL & CELL MODELS