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FLASH GENE
Symbol RC3H2 contributors: mct - updated : 04-09-2014
HGNC name ring finger and CCCH-type zinc finger domains 2
HGNC id 21461
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • NH2 terminal C3HC4 RING finger
  • CCCH-type zinc finger domain
  • C terminal transmembrane domain
  • HOMOLOGY
    Homologene
    FAMILY
  • zinc finger proteins family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • binding and internalization of extracelular DNA
  • RC3H1, RC3H2 maintain tolerance by preventing inappropriate T cell activation and Tfh cell differentiation, and RC3H2 compensates in the absence of RC3H1, but not in the presence of its mutated form
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • RC3H2 shares functions with its paralog RC3H11 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation
  • degradation of MAP3K5 mediated by RC3H2 is an evolutionarily conserved mechanism required for the appropriate regulation of stress responses, including pathogen resistance and cell death
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS