basic FUNCTION
| playing a regulatory role in the processes of inflammation and cell death stimuli |
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involved in activation of CASP1 in response to proinflammatory and apoptotic stimuli |
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activator of caspase 1 in TP53-dependent apoptosis |
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playing a role in the promotion of apoptosis |
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maybe involved in sensing more than one bacterial molecule and may participate in several immune complexes |
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potential role for ubiquitination of NLRC4 that is enabled by its interaction with PSMC5, leading to caspase 8 activation and cell death |
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activates caspase 1 in response to bacterial virulence factors including type III and IV secretion systems (T3SS and T4SS) |
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redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella |
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innate immune recognition of flagellin is shared by transmembrane TLR5 and cytosolic NLRC4/NAIP |
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activates CASP1 and downstream inflammatory response upon sensing cytosolic presence of flagellin during bacterial infection |
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acts as an adaptor through which inflammasome activation signals generated from different NAIP receptors are transduced to CASP1 |
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intracellular receptors, such as NLRP1, NLRP3, NLRP6 and NLRC4, which mediate the assembly of inflammasome complexes leading to the activation of procaspase-1 |
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is a cytosolic NOD (nucleotide binding and oligomerization domain)-like receptor (NLR) that can trigger inflammasome formation in response to bacterial flagellin, an immunodominant antigen in the intestine |
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importance of NLRC4 not only in the innate immune response to bacterial infections but also in the genesis of inflammatory diseases |
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NLRC4-driven IL1B production is critical for the progression of Diabetic Nephropathy |
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NLRC4 and NLRP3, which normally form distinct inflammasomes, activate an lysophosphatidylcholine (LPC)-induced inflammasome and are important in astrogliosis and microgliosis |
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NLRC4 stimulation leads to CASP1 activation followed by a rapid lytic cell death known as pyroptosis |