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FLASH GENE

Symbol

ERP29

contributors: mct - updated : 24-08-2011

HGNC name	endoplasmic reticulum protein 29
HGNC id	13799

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Nervous brain       highly Homo sapiens   brain hindbrain cerebellum     Homo sapiens Reproductive male system prostate       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cells

System Cell Pubmed Species Stage Rna symbol endocrine thyroid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		globular		Hydrophilic
STRUCTURE

motifs/domains	N terminal hydrophobic signal sequence, resembling the thioredoxin domain of protein disulfide isomerase, but lacking its redox-active function due to the absence of an active motif consisting of double cysteines
	C terminal endoplasmic reticulum retention motif KEEL, but lacking the CXXC thioreduxin box motif

mono polymer

dimer

HOMOLOGY

interspecies

homolog to rattus Erp29

Homologene

FAMILY

protein disulfide isomerase family

CATEGORY

chaperone/stress , enzyme , tumor suppressor , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	playing a role in the processing of secretory proteins within the endoplasmic reticulum
	having a function in thyroid cells connected with folding and/or secretion of thyroglobulin
	ERP29 function is critical for the folding/secretion of thyroglobulin (Tg), a major secretory product of thyroid cells
	new role for ERP29 as a chaperone that helps stabilize monomeric GJA1 to enable oligomerization to occur in the Golgi apparatus
	facilitates the transport of secretory proteins in the early secretory pathway
	facilitates processing and transport of proteins in the early secretory pathway
	biological role as a putative chaperone in the endoplasmic reticulum

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

dimerization of ERP29 is crucial for its protein unfolding function

INTERACTION

DNA

RNA

small molecule

protein	regulates GJA1 trafficking and function
	physical interaction with EIF2AK3 and moreover, overexpression of ERP29 enhanced endogenous levels of EIF2AK3 (ERP29 regulates response to doxorubicin by a EIF2AK3-mediated mechanism)

cell & other

REGULATION

Other

not responsive to metabolic stress

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   significantly inhibits proliferation and suppresses tumorigenesis by modulating ER stress signaling and the mesenchymal-epithelial transition in breast cancer cells

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

in mice Erp29 may be one of the important factors involved in sperm fertilization by facilitating sperm-oocyte membrane fusion