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FLASH GENE
Symbol COPZ2 contributors: mct - updated : 28-04-2012
HGNC name coatomer protein complex, subunit zeta 2
HGNC id 19356
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinethyroid   highly
Lymphoid/Immunetonsils   moderately
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer oligo , complex
HOMOLOGY
interspecies homolog to dog COPZ2 (83 pc)
homolog to murine Copz2 (91.2 pc)
Homologene
FAMILY
  • clathrin adaptor complexes small subunit family
  • CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • cis-Golgi network
  • membrane coat
  • basic FUNCTION
  • mediating biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network
  • required for budding from Golgi membranes
  • being essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins
  • involved in regulating the coat assembly
  • required by different tumor cell types but is not essential for normal cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • ER-Golgi transport
  • intracellular protein transport
  • PATHWAY
    metabolism
    signaling
    a component
  • COPG2/COPZ2 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • harbors microRNA 152, which is silenced in tumor cells concurrently with COPZ2 and acts as a tumor suppressor
  • COPZ1 can substitute functionally for the lack of COPZ2 in tumor cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in the majority of tumor cell lines and in clinical samples of different cancer types
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS