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FLASH GENE
Symbol TNS1 contributors: mct - updated : 13-04-2017
HGNC name tensin 1
HGNC id 11973
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveintestine   moderately
Endocrinethyroid   moderately
Lymphoid/Immunespleen   moderately
Nervousnerve   moderately
Reproductivefemale systembreastmammary gland moderately
 female systemovary  moderately
 male systemprostate  moderately
Urinarykidneynephronrenal capsuleglomerulus  Mus musculus
 kidneytubule  moderately Mus musculus
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  predominantly
Connectivebone  highly
Muscular   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a phosphatase tensin-type domain
  • a C2 tensin-type domain
  • a SRC homology 2 domain
  • C-terminal tandem SH2-PTB domain pairing
  • HOMOLOGY
    interspecies homolog to rattus Tns1 (89.3 pc)
    homolog to murine Tns1 (89.9 pc)
    Homologene
    FAMILY
  • subtilisin serine protease family
  • CATEGORY structural protein , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • cell-substrate junction
  • focal adhesion
  • basic FUNCTION
  • may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton
  • required for the maintenance of normal renal function
  • thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility
  • large intracellular proteins believed to link the extracellular matrix to the cytoskeleton via integrins
  • distinct differences in the cellular expression of TNS1, TENC1, and TNS3, suggesting that they may be able to function independently of each other in the kidney and the small intestine
  • is a focal adhesion molecule that links the actin cytoskeleton to integrins and forms signaling complexes through its multiple binding domains
  • is a key component of specialized cellular adhesions (fibrillar adhesions) that bind to extracellular fibronectin fibrils
  • plays an essential role in TGFB1-induced myofibroblast differentiation and myofibroblast-mediated formation of extracellular fibronectin and collagen matrix
  • CELLULAR PROCESS cell organization/biogenesis
    cell migration & motility
    PHYSIOLOGICAL PROCESS development
    text
  • cartilage development
  • PATHWAY
    metabolism
    signaling signal transduction
  • TNS1-DLC1-RhoA signaling axis is critical in regulating cellular functions that lead to angiogenesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with phosphotyrosine-containing proteins
  • binding to actin filaments
  • interacting with STARD8
  • TNS1 enhances RHOA activity in a DLC1-dependent manner
  • cell & other
    REGULATION
    Other rapidly cleaved by calpain II
    tyrosine phosphorylated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    anti-metastatic therapies may benefit from restoring or preserving tensin expression in primary tumors
    ANIMAL & CELL MODELS
    tensin-null mice (Lo, 1997)