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FLASH GENE
Symbol HRASLS contributors: mct - updated : 06-12-2010
HGNC name HRAS-like suppressor
HGNC id 14922
EXPRESSION
Rna function mRNA was expressed in skeletal muscle, testis, heart, brain, and thyroid
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinethyroid    
Nervousbrain    
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cell lineage
cell lines highly in osteosarcoma derived U20S cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal catalytic domain having a similar architecture to classical NlpC/P60 domains, even though their fold topologies are different due to circular permutation in the primary sequence
  • two consensus sequences
  • PXXG involved in binding to Mg2+ and gamma-phosphate when GTP is bound
  • NKXD important for binding guanine ring
  • HOMOLOGY
    interspecies ortholog to murine A-C1
    Homologene
    FAMILY
  • H-REV107-like family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    intracellular,nuclear envelope,lumen
    basic FUNCTION
  • modulator of Ras signaling pathway
  • Ca(2+)-independent phospholipase A(1/2), and it is also a pro-apoptosis protein
  • essential enzyme in retinol metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    Ras signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • GTP
  • magnesium Mg2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    silenced in human gastric cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS