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FLASH GENE
Symbol STX11 contributors: mct - updated : 18-05-2012
HGNC name syntaxin 11
HGNC id 11429
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Lymphoid/Immunelymph node   predominantly
 spleen   predominantly
 thymus   predominantly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunenatural killer Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • several predicted coiled-coil domains
  • cysteine-rich C terminus
  • HOMOLOGY
    interspecies ortholog to rattus Stx11 predicted
    ortholog to murine Stx11
    intraspecies homolog to STX1
    homolog to STX2
    Homologene
    FAMILY syntaxin family
    CATEGORY receptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • regulating protein transport between late endosomes and the trans-Golgi network in cells
  • role in granule exocytosis and in the generation of cell-mediated killing (
  • SNARE protein enriched in cells of the immune system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SNARE protein (VAMP)
  • interacting with VTI1B (by regulating the availability of VTI1B, STX11 regulates trafficking steps between late endosomes, lysosomes and the cell surface in macrophages)
  • STXBP5 interacts with core secretion machinery complexes, such as syntaxin-11/SNAP23 heterodimers, and likely STXBP5 also interacts with the platelet cytoskeleton
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HPLH4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS