Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol STX7 contributors: mct - updated : 11-06-2019
HGNC name syntaxin 7
HGNC id 11442
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil Homo sapiens
Lymphoid/ImmuneT cell Homo sapiens
Skin/Tegumentmelanocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three coiled-coil domains
  • a C terminal transmembrane domain
  • HOMOLOGY
    interspecies homolog to putative homolog of yeast Vam3p
    Homologene
    FAMILY syntaxin family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • late endosomes and and lysosomes colocalizing with VAMP8
  • actively cycles between endosomes and the plasma membrane
  • broadly located in the membranes of the three major cytoplasmic granules of human neutrophils, with a major location in azurophilic granules, which are mainly involved in phagocytosis
  • STX7 colocalizes with RAB7A on late endosomes
  • basic FUNCTION
  • playing a role in vesicle trafficking between the Golgi complex and lysosomes
  • syntaxin 7, syntaxin 8, VTI1B, and endobrevin/VAMP8 function in the fusion of late endosomes
  • may be involved in the intracellular vacuolation induced by Helicobacter pylori-produced cytotoxin VacA
  • regulates vesicle trafficking events involved in phagocytosis and cytokine secretion
  • regulates vesicle trafficking events in phagocytosis
  • might play a role in both exocytosis and phagocytosis in human neutrophils
  • is required for lytic granule release from cytotoxic T lymphocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component STX8 belongs to the endosomal SNARE complex which also contains STX7, VTI1B and VAMP8
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with alpha SNAP (SNAPA), NSF
  • VAMP8
  • RAB-GTPase
  • interacting with CSF1 (effects of CSF1 on STX7 may provide a mechanism for the regulation of macrophage effector functions by CSF1)
  • endosomal SNARE proteins physically and functionally interact with CFTR
  • UNC13D binding to STX7 was significantly increased by calcium
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS