Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NXF2 contributors: - updated : 20-04-2006
HGNC name nuclear RNA export factor 2
HGNC id 8072
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatogonia
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-domain required for interaction with KIF17
  • four leucine-rich repeat,RNP-type RNA6 -binding domain-(RBD)
  • a nuclear transport, factor 2 (NF2) like domain and ubiquitine-associated domain
  • a UBA-like domain
  • a RNA recognition motif (RRM) domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Nxf2
    homolog to zebrafish Dr.6607
    homolog to Drosophila sbr
    homolog to C.elegans nxf-1
    intraspecies homolog to NXF1
    Homologene
    FAMILY family of nuclear RNA export factor genes
    CATEGORY RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope
    text associated with the nuclear envelope
    basic FUNCTION
  • involved in mRNA export from the nucleus to the cytoplasm
  • a nucleo-cytoplasmic mRNA transporter, playing additional roles in the cytoplasmic localization of mRNAs through interactions with cytoplasmic motor proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text
  • mRNA-nucleus export
  • protein-nucleus import
  • PATHWAY
    metabolism
    signaling
    a component heterodimerized with NXT1 AND NXT2
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • NXT1
  • NXT2
  • E1B-AP5
  • the REF proteins
  • nucleoporins (Nup62, Nup153 and Nup214)
  • interacting with KIF17
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS