basic FUNCTION
| nucleocytoplasmic protein with functions consistent with its postulated role as a tumor suppressor protein |
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may be involved in transcriptional and post-transcriptional control pathways |
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may be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression |
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mediating the transcriptional outputs of beta-catenin/Armadillo |
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in the context of the PAF1 complex, mediates repression of the MYC proto-oncogene through both transcriptional and posttranscriptional mechanisms |
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nuclear protein that possesses anti-proliferative properties |
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is required for nuclear transduction of the Wnt/Wg signal and depends on the recruitment of Pygopus proteins |
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playing a role as an inhibitor of cell cycle progression |
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may have a role as an important regulator of transcription |
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has a critical role in cell growth |
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having a proapoptotic activity likely important in its role as a tumor suppressor and a functional role for the NLS is required in this activity |
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potentially facilitates association of 3prime mRNA processing factors with actively-transcribed chromatin and support the importance of links between tumor suppression and mRNA maturation |
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implicated in apoptosis and growth arrest |
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may exert both transcriptional and, through CPEB1, translational control over a subset of target genes and that loss of parafibromin (and CPEB1) function may promote tumorigenesis in part by conferring resistance to nutritional stress |
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required for the maintenance of histone 2B monoubiquitination |
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RTF1, CDC73, and LEO1 have all been shown to play a role in recruitment of PAF1C to chromatin at active genes |