basic FUNCTION
| playing an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing |
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restricts cell numbers by functioning as a dual regulator of cell proliferation and apoptosis |
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required to enhance STK4-mediated apoptosis and thus is a critical player in an STK4-driven cell death signaling pathway |
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playing a crucial role in cell-cycle exit and epithelial terminal differentiation |
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key mediator of STK4 signalling in the coordinate coupling of proliferation arrest with terminal differentiation for proper epithelial tissue development in mammals |
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allows RASSF1 to modulate TP73 independently of the hippo pathway |
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essential component of the ability of RASSF1 to promote apoptosis and to stimulate TP73 |
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potential human tumor suppressor and a proapoptotic effector of RASSF1 |
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potential positive feedback loop, where Hippo stabilises its own positive regulator by antagonising HERC4-mediated degradation of SAV1 |
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SAV1 worked as a cancer suppressor in pancreatic ductal adenocarcinoma |
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scaffold protein SAV1 promotes the activation of the MST-LATS kinase cascade |
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Hippo signaling component, that inhibits AKT1, a function independent of its role in Hippo signaling |