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FLASH GENE
Symbol KPNA5 contributors: - updated : 23-09-2004
HGNC name karyopherin alpha 5 (importin alpha 6)
HGNC id 6398
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • N terminal importin beta binding domain
  • eight armadillo/beta catenin-like repeats
  • C terminal acidic region
  • HOMOLOGY
    interspecies homolog to C-Elegans Ima2
    intraspecies homolog to SRP1 (KPNA1)
    Homologene
    FAMILY importin alpha protein family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in nuclear localization signal(NLS)- dependent protein import into the nucleus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the NLS import receptor including an heterodimer of importin alpha and beta
  • INTERACTION
    DNA
    RNA
    small molecule
    protein binding the nuclear localization signal NLS of nuclear proteins
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS