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FLASH GENE
Symbol SUPT4H1 contributors: mct - updated : 09-10-2013
HGNC name suppressor of Ty 4 homolog 1 (S. cerevisiae)
HGNC id 11467
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivesalivary gland   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal zinc-finger domain that at least in yeast is essential for biochemical activity
  • HOMOLOGY
    interspecies homolog to yeast spt4 (suppressor of Ty)
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • putative chromatin structure regulator
  • may be involved in mRNA capping, homologous DNA recombination, and transcription-coupled DNA repair
  • can aid RNA polymerase II processivity by reducing dissociation of polymerase from the template
  • exert its role in transcriptional regulation, and possibly in other nuclear processes, as parts of the DSIF complex
  • is selectively required for transcription through extended trinucleotide repeats
  • is required for the transcriptional machinery to proceed through a long expansion of the CAG repeat sequence, but is dispensable for transcription of a region containing a short stretch of CAG repeats
  • SUPT4H1, SUPT5H can function independently in multiple transcription-coupled steps of class-switch recombination (CSR)
  • eukaryotic SUPT4H1-SUPT5H complex appears to couple chromatin modification states and RNA processing to transcription elongation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component SUPT4H1/SUPT5H complex, termed DRB-sensitivity inducing factor (DSIF) is a dual regulator of transcription that stimulates, or, when cooperating with negative elongation factor (NELF), represses RNA polymerase II (RNAPII) elongation
  • DSIF is composed of the two subunits, SUPT4H1 and SUPT5H
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS