basic FUNCTION
| putative chromatin structure regulator |
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may be involved in mRNA capping, homologous DNA recombination, and transcription-coupled DNA repair |
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can aid RNA polymerase II processivity by reducing dissociation of polymerase from the template |
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exert its role in transcriptional regulation, and possibly in other nuclear processes, as parts of the DSIF complex |
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is selectively required for transcription through extended trinucleotide repeats |
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is required for the transcriptional machinery to proceed through a long expansion of the CAG repeat sequence, but is dispensable for transcription of a region containing a short stretch of CAG repeats |
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SUPT4H1, SUPT5H can function independently in multiple transcription-coupled steps of class-switch recombination (CSR) |
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eukaryotic SUPT4H1-SUPT5H complex appears to couple chromatin modification states and RNA processing to transcription elongation |