basic FUNCTION
| regulator of hematopoietic growth and differentiation, whose loss confers a block in differentiation advantage to myeloid leukemic cells |
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capable of potential tumor suppressor activity by gene dosage or other epigenetic mechanisms |
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novel regulator of hematopoietic growth and differentiation, whose loss confers a block in differentiation advantage to myeloid leukemic cells |
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may be playing an important role in transcriptional regulation |
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may play a critical role in leukemia pathogenesis |
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critical tumor suppressor in B lymphoid neoplasms |
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plays a role similar to SSBP1 in DNA damage-response pathways |
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SSBP1 and SSBP2 form two separate complexes with similar structures, and both are required for efficient homologous recombination (HR)-dependent repair of DSBs and ATM-dependent signaling pathways |