motifs/domains
| a N terminal luminal/extracellular negatively charged domain |
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two hydrophobic transmembrane segments (TM2) |
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a conserved C terminal region |
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a reticulon domain |
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two major inhibitory regions, first is a stretch in the middle (AA 567-748), restricting neurite outgrowth and cell spreading and induces growth cone collapse |
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second is the extracellular 66 AAs loop, Nogo-66 capable of inhibiting neurite growth and inducing growth cone collapse, with N-terminal 40 AA named Nogo-40 |
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A 172-AAs N-terminal region and a 37-AAs C-terminal region both could inhibit neuronal differentiation and promoted glial cell formation |
SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytoskeleton
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| intracellular,nuclear envelope,ext
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text
| anchored to membranes of the endoplasmic reticulum through its carboxy-terminal regions |
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synaptic localization of Nogo-A ( |
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association with cytoskeletal structures and the base of filopodia, but not with focal or podosomal adhesion sites of monocyte-derived macrophages, also associated with the tubulin network, but not accumulated in the Golgi region |
basic FUNCTION
| neurite outgrow inhibitor, limiting axonal regeneration after nervous injury |
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role central in sporadic and familial amyotrophic lateral sclerosis |
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multidomain protein containing several discrete regions with growth inhibitory functions |
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regulating, in association with RTN4R, CNS axonal plasticity and recovery from injury |
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can modulate the anti-apoptotic activity of BCL2L1 and BCL2 by binding with them and can change their localization to the ER |
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participate in the neuronal responses stemming from hippocampal formation during senescence, and particularly in Alzheimer disease |
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RTN4 and MAG are differently involved in oligodendrocyte maturation , suggesting that RTN4 may influence also remyelination in pathological conditions such as multiple sclerosis |
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N terminus of Nogo-B promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells ( |
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Nogo-B is a regulator of vascular homeostasis ( |
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Nogo A is involved in central nervous system autoimmune demyelination ( |
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role of Nogo-A for myelin formation in the developing optic nerve ( |
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endogenous regulator of inflammatory tissue remodeling and wound healing that is mediated, in part, via impaired macrophage homing to ischemic tissue and wounds |
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role in neuronal migration ( |
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neuronal form plays an important role in regulating cytoskeletal re-organization without the requirement of signaling through its cognate receptor (RTN4R) |
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developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching |
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plays a major role in stabilizing and maintaining the architecture of hippocampal pyramidal neurons |
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functioning as a negative regulator of neuronal growth, leading to stabilization of the CNS wiring at the expense of extensive plastic rearrangements and regeneration after injury |
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may have roles in the regulation of endoplasmic reticulum (ER) structure, processing of amyloid precursor protein and cell survival |
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physiological roles of RTN4, MAG, OMG in processes, such as development, neuronal homeostasis, plasticity, and neurodegeneration |
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endothelial RTN4 regulates leukocyte transmigration and intercellular adhesion molecule-1 (ICAM1)-dependent signaling, and acute inflammation |
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could play a role in the regulation of Purkinje cells (PCs) connectivity |
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distinct biological function for RTN4 expressed by neurons for the development of synaptic connections in the cerebellum |
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is a myelin associated protein and one of the most potent neurite growth inhibitors in the central nervous system |
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loss of RTN4, reduces GRIA3 expression and causes hyperexcitability in hippocampal CA3 circuits |
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RTN and CKAP4 therefore regulate lumenal ER nanodomain heterogeneity, interaction with ER-resident proteins, and dynamics in peripheral ER tubules |
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plays a role in the development and progression of cancer |
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both RTN4 and CKAP4 ( regulate the recruitment of BAX to ER and mitochondrial membranes to enable cytochrome c release and apoptosis |
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strong correlation between the local RTN4 density and the local ER membrane curvature |