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FLASH GENE
Symbol NOP58 contributors: mct - updated : 26-08-2014
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Epithelial    
cells
SystemCellPubmedSpeciesStageRna symbol
 digestive
cell lineage myeloid cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative Sno RNA binding domain
  • a highly charged C terminal domain
  • a consensus phosphorylation sites
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Nop5/Nop58
    intraspecies homolog to NOP56
    Homologene
    FAMILY
  • NOP5/NOP56 family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,coiled bodies (Cajal)
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • essential nucleolar protein
  • involved in fundamental cellular growth processes
  • NOP56 and NOP58 are required for ribosome biogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • second common component of the box C+D snoRNPs to be identified and the first to be shown to be required for the stability and for the synthesis of these snoRNAs
  • INTERACTION
    DNA
    RNA binding to the box C/D family of SnoRNAs
    small molecule
    protein
  • RUVBL2, RUVBL1 efficiently bridge interactions between the core box C/D proteins NOP56 or NOP58 and NHP2L1
  • cell & other
    REGULATION
    Other SUMOylation is essential for high-affinity NOP58 binding to snoRNAs
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS