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FLASH GENE
Symbol XPNPEP1 contributors: mct - updated : 26/09/2008
HGNC name X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
HGNC id 12822
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Endocrinepancreas   highly
Nervousbrain    
Respiratorylung    
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal lowly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a proton shuttle and five divalent metal ligand sites
  • a C terminal hexahistidine tag, catalytic domain coordinating two metal ions and sharing a similar fold with other prolyl aminopeptidases
  • mono polymer dimer
    HOMOLOGY
    interspecies homolog to E.coli methionine aminopeptidase
    Homologene
    FAMILY
  • pita-bread-fold protein family
  • metallopeptidase family M24
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text cytosolic
    basic FUNCTION
  • catalyze the removal of a penultimate prolyl residue from the N termini of peptides
  • playing a role in the maturation and degradation of peptide hormone, neuropeptide and tachykinin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • manganese Mn2+
  • cobalt Co2+
  • protein
  • can degrade bradykinin, a blood pressure-regulating peptide
  • cell & other
    REGULATION
    inhibited by by the specific peptide inhibitor apstatin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS