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FLASH GENE
Symbol CLK4 contributors: - updated : 29-08-2006
HGNC name CDC-like kinase 4
HGNC id 13659
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus   highly
 liver   highly
Nervousbrain    
Urinarykidney    
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  predominantly
Muscular   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text highly in umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to rattus Clk4 (97.5pc)
ortholog to murine Clk4 (97.1pc)
ortholog to chicken CLK4 (83.6pc)
Homologene
FAMILY
  • CDC2/CDC28-like kinase family
  • Ser/Thr protein kinase family
  • Lammer subfamily
  • CATEGORY enzyme , receptor membrane
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • phosphorylating serine- and arginine-rich proteins of the spliceosomal complex
  • may be a constituent of a network of regulatory mechanisms that enable serine- and arginine-rich proteins to control RNA splicing
  • required for the regulation of alternative splicing of MAPT/TAU
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with and inducing the nuclear redistribution of SR proteins SFRS* (see symbols)
  • UBL5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS