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FLASH GENE
Symbol WRAP73 contributors: mct - updated : 04-01-2017
HGNC name WD repeat containing, antisense to TP73
HGNC id 12759
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
 tonsils   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectivebone   
Connectivecartilage   
cells
SystemCellPubmedSpeciesStageRna symbol
 chondrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two WD repeats
  • HOMOLOGY
    intraspecies homolog to HPRP4P
    Homologene
    FAMILY
  • WD repeat gene family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • inhibitor of endochondral ossification (role in regulation of ectopic ossification)
  • the conserved WRAP73-SSX2IP complex plays a critical role in controlling proper spindle length and orientation
  • satellite and centriolar component
  • WRAP73 and CEP135 have strongly overlapping functions in ciliogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • WRAP73 formed a complex and partially colocalised with SSX2IP
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WRAP73 interacts with the satellite proteins SSX2IP and PCM1 as well as the centriolar proximal end component CEP135
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS