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FLASH GENE
Symbol CCL3L1 contributors: SGE/npt - updated : 13-07-2010
HGNC name chemokine (C-C motif) ligand 3-like 1
HGNC id 10628
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunetonsils    
Reproductivefemale systembreastmammary gland  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
isoforms Precursor
HOMOLOGY
interspecies homolog to murine Ccl3 (76.1pc)
homolog to rattus Ccl3 (77.2pc)
intraspecies homolog to SCYA3L2
paralog to CCL3
Homologene
FAMILY
  • intercrine beta (chemokine CC) family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • attracting and activating leukocytes
  • having an anti-HIV-1 activity (binding to CCR5 inhibits HIV entry)
  • should be a potential chemokine to protect against neuronal injury in HIV-1 gp120-related neuronal toxicity (Chun 2009)
  • increased CCL3L1 expression may enhance inflammatory responses and increase the chance of autoimmune disease (McKinney 2008)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling, G protein linked receptor signaling pathway
    a component
  • precursor cleaved into two chains LD78-beta (3-70) and LD78-beta (5-70) by proteolytic cleavage after secretion, probably by DPP4
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to CCR3 and CCR5 receptor
  • binding to several chemokine receptors including chemokine binding protein 2
  • ligand for CCR1
  • cell & other
    REGULATION
    Other LPS stimulation of peripheral blood mononuclear cells increased CCL3L1 expression (Townson 2002)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to HIV/acquired immunodeficiency syndrome (AIDS)
    Variant & Polymorphism other
  • a low copy number is associated with markedly enhanced HIV/acquired immunodeficiency syndrome (AIDS) susceptibility
  • lower CCL3L1 gene copy number compared to the population median is associated with chronic hepatitis C (Grünhage 2010)
  • CCR5-59029 AG genotype and CCL3L1 gene dose appear to have synergistic or interactive effects and are expected to be involved in the host innate resistance to HIV-1 infection (Rathore 2009)
  • copy number of CCL3L1 influences risk of systemic lupus erythaematosus (SLE) and modifies the SLE-influencing effects associated with the CCR5 genotypes (Mamtani 2008)
  • Candidate gene
    Marker
    Therapy target
  • CCL3L1-CCR5 variations may be useful in identifying patients requireng earlier initiation of highly active antiretroviral therapy (Ahuja 2008)
  • ANIMAL & CELL MODELS