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FLASH GENE
Symbol ADD3 contributors: - updated : 31-03-2006
HGNC name adducin 3 (gamma)
HGNC id 245
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
Urinarykidneyrenal medulla  highly
 kidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal globular protease resistent domain
  • a potential protein kinase C phosphorylation site
  • a calmodulin binding site
  • a C terminus homolog to MARCKS proteins, alternatively spliced
  • mono polymer homomer , heptamer
    HOMOLOGY
    Homologene
    FAMILY aldolase class II family, adducin subfamily
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma
    INTERACTION
    DNA
    RNA
    small molecule
    protein calmodulin binding
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS