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FLASH GENE
Symbol WNT11 contributors: mct - updated : 29-08-2016
HGNC name wingless-type MMTV integration site family, member 11
HGNC id 12776
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineparathyroid   highly
Reproductivefemale systemovary   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion secreted
at STAGE
physiological period fetal, pregnancy
Text in the perichondrium of the developing skeleton and in the tips of ureteric buds, liver, kidney, heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cysteine rich, with a zinc finger-like motif
  • five glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (Wg) segment polarity gene
    Homologene
    FAMILY
  • WNT family
  • frizzled gene subfamily
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • ligand for the members of the frizzled members of receptors,modulating cell fate and cell behavior during vertebrate development
  • not required for cardiac differentiation, but functioning in regulation of cardiac morphogenesis
  • may be playing an important role in carcinogenesis through activation of the WNT signaling pathway
  • may be a key regulator of cardiac muscle cell proliferation and differentiation during heart development
  • has an essential role in the oriented elongation of the myocytes
  • required to control myocyte orientation and the action of the neural tube on the polarized elongation of myocytes is mediated, at least in part, by WNT11
  • involved in coordination of key signaling pathways
  • promotes osteoblast maturation and mineralization, through RSPO2
  • regulates the integration of intracellular and extracellular Ca2+, while also tuning dynamic relationships between subcellular Ca2+ domains, and refinement of electrical coupling by Wnt signals may be an important factor not only in cardiogenesis, but also in the establishment and maintenance of other epithelia in development
  • promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals
  • WNT5A and WNT11 are essential regulators of the response of second heart field progenitors to WNT/CTNNB1 signaling and they act by restraining WNT/CTNNB1 signaling during cardiac development
  • plays a crucial role in regulating MSC chondrogenic differentiation
  • WNT5A and WNT11 regulate epithelial-mesenchymal transition (EMT) by inducing p38 (MAPK14) phosphorylation
  • plays an important role in human mesenchymal stem cells (hMSCs) for enhancing the osteogenesis in an infectious environment
  • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS development
    text skeleton, kidney, lung, heart
    PATHWAY
    metabolism
    signaling signal transduction
    WNT signaling pahway, JNK/AP-1 and NF-kappaB signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a direct target of ERG (potent ERG induction promoted morphological transformation through WNT11 signals
  • WNT-11/FZD7 controls cell adhesion by forming separate adhesion-modulating complexes (AMCs) with the paraxial protocadherin PCDH8 and C-cadherin via distinct FZD7 interaction domains
  • WLS has different roles in the polarized secretion of WNT11 and WNT3A and glycosylation processing of Wnts decides their secretory routes
  • stimulates proliferation, migration and invasion of cancer-derived cells, and increases activity of matrix metalloproteinase (MMP2 and MMP9)
  • significant correlation between WNT5B and WNT11 overall staining and presence of calcification, lipid score, fibrosis, and microvessels, in aortic valve calcification
  • cell & other
    REGULATION
    induced by hypoxia
    Other transcription of WNT11 is regulated primarily by HIF1A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal and gastric cancer
    Susceptibility to high bone mass syndrome
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    as a possible target for cancer therapies, especially for tumors treated with antiangiogenic therapy
    ANIMAL & CELL MODELS
    WNT11 is required for heart formation in Xenopus embryos. This function is conserved in higher vertebrates (mice). The effect is mediated by non-cammical Wnt signaling which involves protein kinase C and Jun amino-terminal kinase