Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol VASP contributors: mct/npt/pgu - updated : 24-02-2014
HGNC name vasodilator-stimulated phosphoprotein
HGNC id 12652
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Digestiveintestinesmall intestine  highly
Reproductivefemale systemuteruscervix highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal EVH1 domain binding D/EFPPPPXD motifs and targeting VASP to focal contacts
  • a central proline rich domain binding profilin,
  • SH3, WW domains
  • a C terminal EVH2 oligomerization domain binding F-actin
  • EVH2 domain induces and maintains clustering of the barbed ends of actin filaments, which putatively corresponds to a transition from lamellipodial to filopodial localization
  • EVH1 domain, together with the GAB motif in the EVH2 domain, helps to maintain at the growing barbed ends
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • Ena/VASP family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text Vimentin colocalized with VASP and PKG in endothelial cells
    basic FUNCTION
  • involved in cGMP and cAMP mediated inhibition of agonist-induced platelet aggregation
  • by linking profilin to zyxin/p83, VASP may participate in spatially confined profilin-regulated F-actin formation
  • negative regulator of cell motility intracellular histeria lacterium translocation
  • key regulator of dynamic actin structures like filopodia and lamellipodia
  • actin-binding protein that regulates actin polymerization and bundling via direct interaction with both globular (G) and filamentous (F) actin
  • involved in force-mediated adherens junction strengthening
  • have a role beyond anticapping activity in filopodia formation
  • like ZYX, is required for establishment of strong epithelial cell–cell adhesions
  • key actin regulator that localize at regions of dynamic actin remodeling, including cellular protrusions and cell-cell and cell-matrix junctions
  • critical for actin cytoskeleton remodeling events involved in the maintenance of functional endothelia
  • central protein in the control of the alveolar-capillary barrier properties during acute lung injury
  • direct interaction of VASP with CXCR2 is essential for proper CXCR2 function and demonstrate a crucial role for VASP in mediating chemotaxis in leukocytes
  • associates with focal adhesions and areas of dynamic membrane activity and regulates actin polymerization
  • involved in actin polymerization and bundling which is critical for spine formation, expansion, and modulating synaptic strength
  • PI(3,4)P&
  • 8322;, RAPH1, and ENA/VASP are involved in the process movement of multipolar migrating cells 8)
  • can catalyze actin polymerization by elongating actin filaments
  • is a critical regulator of actin dynamics and tension generation during the contractile activation of airway smooth muscle (ASM)
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component associated with actin filaments and focal adhesions which form the interface between cytoskeleton and extracellular matrix
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly binds to APBB1IP and co-localizes with them at lamellipodia tips and at focal adhesions in response to Ras activation
  • CXCR2-interacting protein (interaction between CXCR2 and VASP is direct and enhanced by CXCL8 stimulation, which triggers VASP phosphorylation via PKA- and PKCdelta-mediated pathways)
  • interaction between vimentin and VASP constitutes an important step in endothelial cell migration and proliferation
  • ZYX recruits Enabled/vasodilator-stimulated phospho-proteins (ENAH/VASP) to promote actin assembly
  • interacting with ZYX
  • VASP is a novel substrate for PRKD1(PRKD1 directly phosphorylates VASP at two serine residues, Ser-157 and Ser-322)
  • FBLIM1 is a novel cell-matrix adhesion protein known to interact with VASP and be localized both at cell-matrix and cell-cell adhesions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    present in apical tight junctions in normal epithelium but were dislocated to the basolateral position in patients with inactive Crohn disease (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS