Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol WNT2B contributors: mct - updated : 04-09-2018
HGNC name wingless-type MMTV integration site family, member 2B
HGNC id 12781
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
Reproductivefemale systembreast   
 male systemtestis  highly
Visualeye   highly
cell lineage
cell lines glioblastoma, gastric cancer, cervical cancer cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain, lung, kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal hydrophibic domain
  • a WNT core domain with 24 cysteine residues
  • two N-glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (wg) segment polarity gene
    Homologene
    FAMILY WNT family
    CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
    text
  • in the presence of ACSL5, WNT2B was unable to translocate into the nucleus and was enriched in mitochondria, which was paralleled by a significant decrease in Wnt activity
  • basic FUNCTION
  • modulating cell fate and cell behavior during vertebrate development
  • implicated in eye ciliary body induction
  • role for the lens in maintenance of WNT2B expression
  • WNT2B primarily plays a supportive role in gastrulation and organogenesis, functioning redundantly with canonical Wnts, such as WNT2, in numerous tissues
  • is likely required to maintain normal intestinal stem cells (ISCs) numbers and/or activity in the duodenum
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is one of canonical WNTs transducing signals through Frizzled (FZD) and LRP5/LRP6 receptors to beta-catenin-TCF/LEF signaling cascade
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DIAR9
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in several breast cancer cell lines
    constitutional       gain of function
    abnormal upregulation in the levels of WNT2B and WNT7B in neural tube defects (NTDs)
    tumoral     --over  
    of GLI1 and WNT2B might play a pivotal role during tumorigenesis of pancreatic cancer, and the high expression of WNT2B might be associated with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking Wnt2b were viable, fertile, and displayed a normal life span, however, the olfactory bulb in adult Wnt2b mutant mice was significantly reduced in length