protein
| CD34 |
|
MCAM1 |
|
KLF2 directly activates the promoters of SELL and sphingosine-1-phosphate receptor 1, whose expression is critical for T cell egress from the thymus and homing to the lymph nodes |
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interacting with CD44 (TM domains of SELL and CD44 play a crucial role in cell adhesion under flow by targeting receptors to microvilli or the cell body, respectively) |
|
CALM1 associates with the cytoplasmic domain of SELL to regulate ectodomain shedding of L-selectin on the other side of the plasma membrane |
|
interacting with KLF2 |
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LRRC32 expression appears to alter the surface expression of activation markers of T cells such as SELL |
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MUC16 is the SELE and SELL ligand expressed by metastatic pancreatic cancer cells |
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PAEP interacts with SELL to induce IL6 production in monocytes/macrophages by activating the ERK signaling pathway |
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over-activation of ADAM17 in NK cells may be detrimental to their effector functions by down-regulating surface expression of FCGR3A and SELL |
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EZR and MSN play mutually exclusive roles in modulating SELL signalling and shedding to control protrusion dynamics and polarity during monocyte transendothelial migration (TEM) |