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FLASH GENE
Symbol RAP2A contributors: mct - updated : 06-11-2014
HGNC name RAP2A, member of RAS oncogene family
HGNC id 9861
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestine   
Lymphoid/Immunelymph node   highly
 thymus    
Nervousbrain    
Respiratoryrespiratory tractlarynx  highly
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythroblast
Blood/Hematopoieticerythrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Rap2a
Homologene
FAMILY Ras family of small GTP-binding proteins
CATEGORY signaling
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,endosome
intracellular,cytoplasm,cytosolic
text
  • localizing and recruiting TNIK to the recycling endosomes in a palmitoylation-dependent manner (Uechi, 2009)
  • basic FUNCTION
  • involved in small GTPase mediated signal transduction
  • playing a possible role in membrane shedding
  • functioning as a slowly responding molecular switch in the RAP1A signaling cascade
  • is a molecular link that couples the formation of microvilli in intestinal cell directly to the preceding cell polarization
  • endothelial barrier resistance is determined by the combined antagonistic actions of RAP1A and RAP2A
  • acts via TNIK to regulate the stability of LRP6 receptor for WNT/CTNNB signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • NEDD4/RAP2A/TNIK signaling pathway regulates neurite growth and arborization in mammalian neurons
  • a component
  • NEDD4, the serine/threonine kinase TNIK, and RAP2A form a complex that controls NEDD4-mediated ubiquitination of RAP2A
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ARHGAP29, putative specific effector of RAP2A to regulate RHO
  • MAP4K4 is a putative effector of RAP2A mediating the activation of JNK by RAP2A
  • by binding to phosphatidic acid enriched at the apical membrane, RAPGEF2 locally activates RAP2A resulting in induction of brush border formation via a pathway that includes the polarity players TNIK, STK26 and Ezrin
  • RAP2C is spatially segregated from RAP2A signaling as it is not enriched at the apical membrane after polarization
  • cell & other
    REGULATION
    activated by guanine nucleotide-exchange factors (GEF) EPAC,
    and EPAC2 in a cAMP-dependent manner, and GFR
    Other requires palmitoylation for membrane association and TNIK activation (Uechi, 2009)
    requires palmitoylation for induction of TNIK-mediated phenotype, the suppression of cell spreading (Uechi, 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in sporadic breast cancer, grade I
    constitutional     --low  
    age-downregulated in frontal cortex
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS