basic FUNCTION
| regulator of Ca2+ dependent exocytosis of neurotransmitter |
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playing a key role in neurotransmitter release and synaptic plasticity |
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selective role in spontaneous transmitter release at the neuromuscular junction |
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RAB3-induced modifications to primed vesicles causes a transient increase in the transduction efficacy of synaptic action potential trains and optimizes the encoding of synaptic information at an intermediate spike frequency range |
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small GTP binding protein associated with presynaptic vesicles that is thought to regulate vesicle targeting to active zones |
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potential role in trafficking and targeting vesicles to the active zones |
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may regulate SNAP29-mediated membrane fusion during myelination |
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specifically stimulates morphological differentiation of mature oligodendrocytes and thus may be part of the necessary machinery for myelin membrane biogenesis |
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having an additional and unexpected function in the localization of presynaptic proteins to active zones |
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with RAB27B, probably in concert with RAB3B and RAB3C, is involved in synaptic vesicles exocytosis |
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synapsin II and RAB3A have separate roles in maintaining the total store of synaptic vesicles and cooperate in promoting the latest steps of neuronal secretion |
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play two distinct stimulating roles for large dense-core vesicles fusion in embryonic chromaffin cells, by facilitating vesicle biogenesis and stabilizing the primed vesicle state |
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RAB3A and RAB27A regulate late steps during dense-core vesicle exocytosis in neuroendocrine cells |