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FLASH GENE
Symbol SRGN contributors: mct - updated : 20-08-2011
HGNC name serglycin
HGNC id 9361
EXPRESSION
Rna function in endothelial cells and smooth muscle cells
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunelymph node   highly
Respiratorylung   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectiveadipose    Homo sapiens
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet Homo sapiens
Lymphoid/Immunemacrophage Homo sapiensAdult
Lymphoid/Immunenatural killer Homo sapiensAdult
Lymphoid/ImmuneT cell Homo sapiensAdult
not specificadipocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 18 AA glycosaminoglycan-attachment region
  • HOMOLOGY
    Homologene
    FAMILY
  • serglycin family
  • CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,granule
    text core of secretory granule
    basic FUNCTION
  • may be acting as a mediator of granule-mediated apoptosis
  • hematopoietic cell granule proteoglycan, which may be important for neutralizing hydrolytic enzymes
  • may be involved in the retention of the proteases after their entry into secretory vesicles
  • important role in secretory processes in human monocytes
  • hematopoietic cell secretory granule proteoglycan, crucial for storage of specific secretory proteins in mast cells, neutrophils, and cytotoxic T lymphocytes
  • serglycin proteoglycan is a novel player in mast cell apoptosis
  • major proteoglycan in human endothelial cells, mainly secreted to the apical medium and implicated in chemokine secretion
  • potential role for serglycin in regulating proinflammatory activities of endothelial cells, possibly by affecting the storage and/or secretion of chemokines
  • adipocytokine highly expressed in epicardial adipose tissue (EAT)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by EBV
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in highly metastatic cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serves as an independent prognostic indicator of metastasis-free survival and disease-free survival in nasopharyngeal carcinoma patients
  • Therapy target
    ANIMAL & CELL MODELS
  • SG-/- murine platelet function deficiencies are related to inadequate packaging and secretion of selected alpha-granule proteins and reduced secretion of dense granule contents critical for platelet activation (