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FLASH GENE
Symbol PKLR contributors: mct/npt - updated : 01-06-2009
HGNC name pyruvate kinase, liver and RBC
HGNC id 9020
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Skin/Tegumentskin   moderately
Urinarykidney   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerthrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
interspecies homolog to rattus Pklr (92.6 pc)
homolog to murine Pklr (91.6 pc)
Homologene
FAMILY
  • pyruvate kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • catalyzing the production of phosphoenolpyruvate from pyruvate and ATP
  • plays an important role in the Tp53-mediated inhibition of translation under conditions of DNA damage (Yoon 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , energetic
    signaling
    final step of glycolysis
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Mg2+
  • K+
  • protein TP53 target gene and plays an important role in the tumor-suppressor function of TP53 (Yoon 2009)
    cell & other
    REGULATION
    induced by TP53 in response to the stress of DNA damage, plays an important role in the tumor-suppressor function of TP53 (Yoon 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s) PKLR , PYKH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS