protein
| interacting wth SPP1 (regulates SPP1 transcription by abrogating NF-kappaB activation) |
|
recruits HDAC1 to the NF-kappaB binding site of the PLAU promoter, modulates histone acetylation of RELA on the PLAU promoter, leading to reduced NF-kappaB binding activity on its consensus sequence, and reduced transactivation of PLAU expression |
|
association of SNX6 with breast cancer metastasis suppressor 1 (BRMS1) protein |
|
ING4 is a downstream target of BRMS1 in regulating tumor angiogenesis |
|
inhibits the activity of NFKB1, a well-known transcription factor that plays significant roles in tumor progression. Moreover, and coordinately regulates the expression of metastasis-associated microRNA known as metastamir ( |
|
|
|
CUL3, a component of E3 ubiquitin ligase, is a new binding partner of BRMS1 and the interaction between BRMS1 and CUL3 is mediated by the SPOP adaptor protein |
|
suppresses osteopontin (SPP1) expression in Hepatocellular carcinoma cells (HCC) and there is a negative correlation between BRMS1 and SPP1 mRNA expression in HCC tissues |
|
induces polyubiquitination of EP300, resulting in its proteasome-mediated degradation |