basic FUNCTION
| acetyl-CoA carboxylase alpha, biotin dependent |
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catalyzing the synthesis of malonyl-CoA, an intermediate substrate playing a pivotal role in the regulation of fatty acid metabolism and energy production |
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major regulatory enzyme of fatty acid biosynthesis |
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crucial roles in de novo fatty acid biosynthesis and lipogenesis and essential for cancer cell survival |
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involved in the biosynthesis of fatty acids, and malonyl-CoA produced is used as a building block to extend the chain length of fatty acids by fatty acid synthase (FAS) |
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with FABP2 are both key factors of lipogenesis and transport |
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essential role for ACACA-mediated de novo lipogenesis as a regulator of CD8(+) T cell expansion |
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ACACA and ACLY regulate the levels of ETV4 under hypoxia via increased alpha-ketoglutarate |