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FLASH GENE
Symbol LUM contributors: mct - updated : 19-08-2011
HGNC name lumican
HGNC id 6724
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Skeletonappendicular skeletonjoint    Homo sapiens
Skin/Tegumentskin    
Visualeyeanterior segmentcornea highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivedensetendon   Homo sapiens
Epithelialbarrier/liningcorneal stroma  
cells
SystemCellPubmedSpeciesStageRna symbol
 chondrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten leucine-rich repeats (LRR) flanked by cysteine-rich regions
  • a N linked glycosylation site (NKSIT motifs) in the LRR region
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY small-leucine-rich proteoglycans family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix (ECM)
    basic FUNCTION
  • playing a role in the regulation of collagen assembly into fibrils in various connective tissues
  • having a novel regulatory role in keratocan expression at the transcriptional level
  • regulating keratocan
  • stimulates cell migration in the corneal epithelium by activating ERK 1/2, and point to a novel signaling pathway implicated in corneal epithelial cell migration
  • plays pivotal roles in skin collagen fibrillogenesis and wound healing
  • may play a key role in the generation of a new collagen network by fibroblast-like cells
  • endogenous inhibitor of TGFB2 activity, resulting in downstream effector modulation including SMAD2, integrin beta1 and PTK2 to regulate osteosarcoma adhesion
  • reduces tumor growth via induction of fas-mediated endothelial cell apoptosis
  • efficient inhibitor of cell adhesion and migration
  • affects angiogenesis both by interfering with alpha2beta1 receptor activity and downregulating proteolytic activity associated with surface membranes of endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • keratan sulfate proteoglycan one of the three major constituents of the corneal stroma
  • major extracellular component of the fibrous mammalian sclera
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by HMGA2 (transcriptionally repressed by HMGA2 and frequently lost in human high-grade serous papillary carcinoma)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast, pancreas, carcinomas, cervical carcinoma cell lines
    Susceptibility to high myopia
    Variant & Polymorphism other polymorphisms contribute to the development of high myopia
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS