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FLASH GENE
Symbol GTF3A contributors: mct/npt - updated : 04-11-2009
HGNC name general transcription factor IIIA
HGNC id 4662
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systemovary   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
not specificadipocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine C2H2 zinc finger domains
  • a non-finger C-terminal tail with conserved transcription activation domain as well as conserved nuclear localization and nuclear export signals (Hanas 2002)
  • HOMOLOGY
    interspecies homolog to Xenopus
    homolog to C.elegans T08b2.11
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • required for initiation of transcription of 5s RNA
  • initiating transcription of the 5 s ribosomal RNA gene
  • maintaining the stability of transcription of other genes
  • CELLULAR PROCESS nucleotide, transcription, initiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the internal control region (icr) of approximately 50 bases within the 5S RNA gene
    RNA binding to transcribed 5S RNAs
    small molecule metal binding,
  • Zn2+
  • protein
  • FT3A interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS