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FLASH GENE
Symbol HTR7 contributors: mct - updated : 31-05-2014
HGNC name 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
HGNC id 5302
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   predominantly
Nervousbrain    
 brainforebraincerebral cortex  
 brainlimbic systemhippocampus highly Homo sapiens
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Lymphoid    
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
interspecies ortholog to rattus 5HT7
homolog to guinea pig GP2-7
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
text
  • co-localization between the HTR7 receptor and RHOBTB3 at the plasma membrane and in the endoplasmic reticulum
  • basic FUNCTION
  • 5-hydroxytryptamine (serotonin) receptor, activating adenylate cyclase
  • biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen
  • could reside in different dimeric contexts and initiate different signaling pathways, depending on the neuronal circuitry and/or brain region
  • involved in a wide variety of central nervous system (CNS) functions, namely circadian rhythm, depression, thermoregulation, obsessive-compulsive disorder (OCD), anxiety
  • regulated expression of HTR7 and GNA12-protein may represent a molecular mechanism by which serotonin specifically modulates formation of initial neuronal networks during early postnatal development
  • might play a crucial role in shaping neuronal morphology and behaviorally relevant neuronal networks, paving the way to new approaches able to modulate CNS connectivity
  • critical role in immune response and inflammation in the gut
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cardiovascular , circadian
    text
  • circulation
  • circadian variation of expression
  • PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CAV1, specifically localized in cholesterol-enriched lipid rafts, appears to regulate constitutive and agonist-stimulated cell surface levels of HTR7 receptors via a clathrin-independent mechanism
  • RHOBTB3 is a new interaction partner of the HTR7 receptor, and RHOBTB3 strongly inhibits proteasomal degradation of HTR7 receptor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility unlikely to be associated with autistic disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunedigestive
    potential benefit of targeting HTR7 to alleviate the severity of intestinal inflammatory disorders such as inflammatory bowel disease
    ANIMAL & CELL MODELS
  • 5-HT(7)(-/-) mice had specific impairments in memory compilation required for resolving spatial tasks, which resulted in impaired allocentric spatial memory (