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FLASH GENE
Symbol CDKN3 contributors: mct - updated : 14-04-2014
HGNC name cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)
HGNC id 1791
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 intestinesmall intestine   
Lymphoid/Immunelymph node    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, G1, S, checkpoint
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • CDK inhibitor family
  • protein-tyrosine phosphatase family
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • cyclin dependent kinases CDC2 (CDK1) and CDK2 (CDC2/CDK2) inhibitor, may be playing a role in cell cycle regulation
  • has a dual function in cell cycling, and acts as an oncogene in hepatocellular carcinoma
  • is essential for normal mitosis and G1/S transition
  • controls mitosis through the CDK1 signaling axis
  • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text negative control
    PATHWAY
    metabolism
    signaling
    a component stable complex with CDK2
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • dephosphorylates threonine-161 of CDK1 during mitotic exit
  • binds and activates ROCK2 (RNA-mediated downregulation of CDKN3 leads to decreased ROCK2 activity and this, in turn, increases RAC1-mediated invasion)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be used as a novel tumor marker to predict the prognosis of epithelial ovarian cancer (EOC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    antagonism of CDKN3 may be of interest for the treatment of hepatocellular carcinoma
    ANIMAL & CELL MODELS